Researchers at the Ohio State University Wexner Medical Center discovered a novel pathway for hair follicular regeneration with tocotrienols. EVNol SupraBio™ – patented & bioenhanced full spectrum palm tocotrienol complex is shown to upregulate the gene expressions of the “Yamanaka Transcription Factors”, leading to increased fetal characteristics of hair follicular development and promoting anagen hair cycling.
The researchers reported the following findings in the tocotrienol treated mice:
- Significantly increased number of anagen hair follicles;
- Increased epidermal keratinocyte proliferation;
- Significant decreased E-cadherin expression that was associated with high translocation of beta-catenin-Tf3; causing
- Upregulation of the Oct4, Sox9, Klf4, c-Myc and Nanog skin-specifc pluripotent factors;
Ultimately resulting in hair follicular regeneration.
“What we have shown is that Palm TRF can induce hair folliculogenesis, which means that it can enrich the skin stem cell reserves. This novel epidermal pathway of hair follicular regeneration can have widespread impact on skin function including skin aging and repair,” says Prof. Chandan Sen, the lead researcher at Ohio State University Wexner Medical Center.
A previous 2010 human study shows that supplementation with palm mixed-tocotrienol complex (EVNol SupraBio™) at 100mg/day for 8 months leads to improved hair growth in subjects with hair loss issues.