Historical Development

1922

Herbert Evans and Katherine Bishop from University of California- discovered vitamin E in green leafy vegetables.

1924

Scientific name for vitamin E–tocopherol was adopted as vitamin E supported fertility. In Greek, tokos means childbirth while phero means to bring forth.

1936

Vitamin E was discovered in wheat germ oil.

1940

Vitamin E was found to protect people from coronary heart disease

1964

A vitamin E compound was isolated from a rubber plant, Havea brasiliensis and it was named “Tocotrienols”.

1968

National Academy of Sciences

Vitamin E recognized as an essential nutrient officially by the Food and Nutrition Board of the National Academy of Sciences.

1986

Tocotrienol (T3) from barley showed decreased rate of cholesterol synthesis, total and LDL (low-density lipoprotein) when feeding to chicken.

1991

T3 demonstrated hypocholesterolemic effects in an animal and 2 human studies

1994

T3 derived from palm oil exhibited anti-cancer effects in EBV (Epstein – Barr virus) human lymphoblastoid cells.

1997

T3 from palm oil showed antioxidant effects & attenuate carotid atherosclerosis

2000

Nanomolar concentrations of T3 inhibited glutamate-induced neuronal cell death, by Prof Sen.

2003

evnol suprabio logo

A bio-enhanced delivery system (SupraBio® System) for consistent and optimal absorption of T3 was developed.

 

National Institute of Health (NIH)-funded neuroprotective studies (in vitro, in vivo & clinical studies) led by Prof Sen commenced.

2006

T3 demonstrated neuroprotection by antioxidant-independent mechanism.

2007

First clinical study – SupraBio® System on hair growth

2008

First clinical study- SupraBio® System on heart health (arterial compliance)

2010

Palm T3 obtained GRAS status from USFDA First clinical study –SupraBio® System on Immune Support

2011

First T3 conference (Las Vegas) organized by Malaysian Palm Oil Board (MPOB).

2012

First clinical study on SupraBio® System on Liver
Health (Fatty Liver/NAFLD)

2014

First clinical study- SupraBio® System attenuates white matter lesion progression (pre-stroke symptom).